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Yuji CHEN, Qizhi LUO,
《结构与土木工程前沿(英文)》 2009年 第3卷 第4期 页码 352-356 doi: 10.1007/s11709-009-0057-7
关键词: thin-walled box girder with variable cross-sections potential variational theory shear lag large deflection problem
CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 554-562 doi: 10.1007/s11684-017-0543-6
T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advanced refractory B cell malignancy. However, many challenges remain in extending its application toward the treatment of solid tumors. The immunosuppressive nature of tumor microenvironment is considered one of the key factors limiting CAR-T efficacy. One negative regulator of T cell activity is lymphocyte activation gene-3 (LAG-3). We successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using CRISPR-Cas9 mediated gene editing and found that the viability and immune phenotype were not dramatically changed during in vitro culture. LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity in cell culture and in murine xenograft model, which is comparable to standard CAR-T cells. Our study demonstrates an efficient approach to silence immune checkpoint in CAR-T cells via gene editing.
关键词: CAR-T CRISPR-Cas9 LAG-3
Dynamic behavior of superheated steam and ways of control
LI Xu
《能源前沿(英文)》 2008年 第2卷 第1期 页码 25-30 doi: 10.1007/s11708-008-0014-5
关键词: engineering investment Numerous simulation lead/lag temperature
Modeling of shear walls using finite shear connector elements based on continuum plasticity
Ulf Arne GIRHAMMAR, Per Johan GUSTAFSSON, Bo KÄLLSNER
《结构与土木工程前沿(英文)》 2017年 第11卷 第2期 页码 143-157 doi: 10.1007/s11709-016-0377-3
关键词: shear walls wall diaphragms finite element modelling plastic shear connector analytical modelling experimental comparison
Dan V. BOMPA, Ahmed Y. ELGHAZOULI
《结构与土木工程前沿(英文)》 2020年 第14卷 第2期 页码 331-356 doi: 10.1007/s11709-019-0596-5
关键词: non-linear numerical modelling concrete damage plasticity RC flat slabs shear-heads punching shear
Behaviour of self-centring shear walls——A state of the art review
《结构与土木工程前沿(英文)》 2023年 第17卷 第1期 页码 53-77 doi: 10.1007/s11709-022-0850-0
关键词: self-centring shear walls rocking walls energy dissipation seismic performance factors PT loss residual drift
Prediction of the shear wave velocity
Amoroso SARA
《结构与土木工程前沿(英文)》 2014年 第8卷 第1期 页码 83-92 doi: 10.1007/s11709-013-0234-6
关键词: horizontal stress index shear wave velocity flat dilatometer test cone penetration test
On braced trapezoidal corrugated steel shear panels: An experimental and numerical study
《结构与土木工程前沿(英文)》 2023年 第17卷 第3期 页码 396-410 doi: 10.1007/s11709-023-0934-5
关键词: trapezoidal corrugated plate steel shear panel braced steel shear panel experimental study buckling resistance.
Experimental study on shear behavior of reinforced concrete beams with web horizontal reinforcement
Dong XU,Yu ZHAO,Chao LIU
《结构与土木工程前沿(英文)》 2014年 第8卷 第4期 页码 325-336 doi: 10.1007/s11709-014-0080-1
关键词: reinforced concrete beam shear strength web horizontal reinforcement experiments
薛海峰,向锦武,张晓谷,李书强
《中国工程科学》 2007年 第9卷 第9期 页码 58-62
采用多桨叶坐标转换和复数坐标 变换等方法,研究了变距/摆振耦合对直升 机空中共振的影响;推导出完全引入变距/ 摆振耦合的直升机空中共振分析公式,建立 了相应的分析模型和计算程序。利用系统的 特征值研究了直升机空中共振的动不稳定性, 得出变距/摆振耦合对直升机空中共振的影响 ;通过系统的特征向量与各自由度之间的相互 作用(能量关系)的研究,揭示了空中共振机理 ,以某型直升机为例进行了计算分析。研究表明 :正的变距/摆振耦合可以抑制旋翼/机体耦合 系统的动不稳定性,在同时存在挥舞/摆振耦合 和正的变距/摆振耦合时,直升机的旋翼/机体 耦合系统为绝对稳定。
Effect of loading rate on shear strength parameters of mechanically and biologically treated waste
《环境科学与工程前沿(英文)》 2022年 第16卷 第12期 doi: 10.1007/s11783-022-1595-7
● Mechanical behavior of MBT waste affected by loading rate was investigated.
关键词: Mechanically and biologically treated waste Landfill Triaxial test Loading rate Axial strain Shear strength parameter
Micromixing performance of the teethed high shear mixer under semi-batch operation
《化学科学与工程前沿(英文)》 2022年 第16卷 第4期 页码 546-559 doi: 10.1007/s11705-021-2069-3
关键词: high shear mixer semi-batch operation micromixing performance Villermaux/Dushman system segregation index
Predicting the capacity of perfobond rib shear connector using an ANN model and GSA method
Guorui SUN; Jun SHI; Yuang DENG
《结构与土木工程前沿(英文)》 2022年 第16卷 第10期 页码 1233-1248 doi: 10.1007/s11709-022-0878-1
关键词: perfobond rib shear connector shear strength ANN model global sensitivity analysis
Uncertainty of concrete strength in shear and flexural behavior of beams using lattice modeling
《结构与土木工程前沿(英文)》 2023年 第17卷 第2期 页码 306-325 doi: 10.1007/s11709-022-0890-5
关键词: lattice modeling shear failure flexural failure uncertainty deficiency numerical simulation
《结构与土木工程前沿(英文)》 2021年 第15卷 第3期 页码 576-594 doi: 10.1007/s11709-021-0728-6
关键词: fatigue shear hybrid stirrups hybrid reinforcement fiber-reinforced polymer
标题 作者 时间 类型 操作
thin-walled box continuous girder with variable cross-sections in considering effect of large deflection and shearlag
Yuji CHEN, Qizhi LUO,
期刊论文
Modeling of shear walls using finite shear connector elements based on continuum plasticity
Ulf Arne GIRHAMMAR, Per Johan GUSTAFSSON, Bo KÄLLSNER
期刊论文
Nonlinear numerical simulation of punching shear behavior of reinforced concrete flat slabs with shear-heads
Dan V. BOMPA, Ahmed Y. ELGHAZOULI
期刊论文
Experimental study on shear behavior of reinforced concrete beams with web horizontal reinforcement
Dong XU,Yu ZHAO,Chao LIU
期刊论文
Effect of loading rate on shear strength parameters of mechanically and biologically treated waste
期刊论文
Predicting the capacity of perfobond rib shear connector using an ANN model and GSA method
Guorui SUN; Jun SHI; Yuang DENG
期刊论文
Uncertainty of concrete strength in shear and flexural behavior of beams using lattice modeling
期刊论文